Blood Sugar/ Berberine Breakthrough regulation of blood sugar levels - 60 caps

Why buy

Blood Sugar Breakthrough (recently renamed Berberine Breakthrough) is a premium dietary supplement designed to support healthy blood sugar levels, boost metabolism and optimize insulin sensitivity.

Its clinically tested ingredients work synergistically to support metabolic health, improve energy utilization and aid in weight control.

Holistic approach - why does it work as a whole?

This supplement is not built on just one ingredient, but connects:

• Fast-acting berberine for sugar stabilization.
• Vitamins and minerals that support metabolism and ensure sufficient energy.
• Herbal extracts that target carbohydrate digestion, fat burning and cell protection.

The result is a comprehensive solution for:

• Low-carb diet - Provides support in fat burning and energy maintenance.
• Carbohydrate days - Helps process excess sugars without sudden spikes.
• Overall vitality - Supports energy metabolism, reduces sweet cravings and protects cells from stress.

The dosages and formulation in this product are carefully thought out to be effective, safe and easily absorbed.

The combination of dihydroberberine, biotin, chromium and plant extracts form a comprehensive system that supports metabolism and regulates sugar levels, whether you're on a low-carb diet or occasionally indulge in more carbs.

Chart

This graph shows how blood sugar levels behave after a meal - once without the supplement (black curve) and once with the Blood Sugar (Berberine) Breakthrough supplement(red curve).

The black curve (baseline) starts at 104 before the meal, rises sharply to 148 after 30 minutes and then gradually falls to 143, 133, 120 and 113. Thus, the sugar level returns to normal slowly and remains elevated for a long time.

In contrast, the red curve starts at 94, rises only slightly to 112 after 30 minutes, and gradually drops to 101, 99, 90 and 92. Sugar levels are therefore more stable and return to their original values more quickly.

What follows from this? The supplement helps keep sugar levels more stable so there are no sharp fluctuations after meals.

This can mean fewer cravings for sweets, more balanced energy without slumps, and a boost to both metabolism and weight control. If you want to keep your sugar under control and feel better after eating, this supplement can be a good help.

Chart layout for Europe

The chart above shows blood sugar levels in units of mg/dl, which are commonly used in the US. But in Europe we use mmol/l units.

Normal blood sugar levels in a healthy person are between 4 and 6 mmol/l at fasting and 5 to 8 mmol/l after meals. For diabetics, it is recommended to maintain between 6 and 10 mmol/l fasting and between 8 and 12 mmol/l in the latter case.

The control group's (non-supplemented) sugar level starts at 5.8 mmol/l before the meal, which falls within the normal range, but rises sharply to 8.2 mmol/l 30 minutes after the meal. This value is at the borderline of the recommendations for diabetics, and although it gradually decreases afterwards, it still remains higher than would be ideal.

In contrast, the Blood Sugar Breakthrough group starts at 5.2 mmol/l before meals and rises only slightly to 6.2 mmol/l after meals, quickly returning to baseline. It remains within safe limits at all times, indicating a more stable response to food and better sugar control without significant fluctuations.

The supplement helps keep sugar stable and closer to ideal levels, which is beneficial not only for healthy people, but also for those who tend to have higher sugar levels or want to prevent metabolic problems.

Main advantages

• It contains ^{GlucoVantage®} dihydroberberine, which is a more bioactive form of berberine with better absorption and longer potency than conventional forms of berberine*. This form allows the body to use berberine more quickly to boost metabolism, stabilize blood sugar levels, and burn fat.
• It combines biotin (vitamin B7) and chromium, which contribute to normal macronutrient metabolism and the maintenance of normal blood sugar levels.
• It contains plant extracts such as banaba leaf, bitter melon and cinnamon, which have long been studied for their properties related to carbohydrate digestion and taste regulation.
• The formula contains ingredients that help the body manage energy balance and are suitable as a supplement in a low carbohydrate diet.
• It contains ingredients studied for their effect on fat metabolism and maintaining vitality during the day.

*The difference between ^{GlucoVantage®} dihydroberberine and regular berberine HCl:

• Berberine HCl - The traditional form of berberine, which must first be converted to dihydroberberine (the active form) in the body before it can take effect. This process can be less efficient and causes digestive problems in some people.

• ^{GlucoVantage®} dihydroberberine - Already pre-formulated bioactive form that is absorbed faster and has a longer lasting effect. This improves berberine utilization and reduces the risk of side effects such as stomach upset.

This difference makes ^{GlucoVantage®} a more premium version of berberine that is suitable for people looking for better results at lower doses.

Why is berberine in fashion?

Berberine has gained immense popularity due to its ability to support metabolic health and address issues associated with modern eating habits. Diets rich in sugars and processed carbohydrates have led to an increase in insulin resistance, type 2 diabetes and metabolic syndrome.

Berberine is scientifically studied for its ability to maintain healthy blood sugar levels and improve insulin sensitivity, making it a hot topic in the world of health and weight loss. For its effects, it has even earned the nickname "natural Ozempic" because, like prescription drugs, it activates the enzyme AMPK, which promotes fat burning and improves energy balance.

This supplement is also popular with biohackers looking for ways to optimize health through science and dietary supplements. Berberine is promoted for its ability to improve mitochondrial function and thereby increase energy production, further promote fat burning through activation of the AMPK enzyme, and extend cell life through its anti-inflammatory and antioxidant properties.

Contrary to many fads, berberine has actual scientific studies that confirm its effects. Research shows that it improves blood sugar control and insulin response, promotes heart health by lowering cholesterol, and helps with weight loss and fat metabolism.

Due to its efficacy, scientific backing and availability, berberine has become a popular solution for supporting metabolic health, weight control and overall vitality.

Links to studies

• Healthline: Provides an overview of the benefits of berberine, including blood sugar control, weight loss and heart health.
• WebMDdescription : Offers an overview of the uses of berberine, its benefits and possible side effects.
• Cleveland Clinica: Addresses the potential of berberine for insulin resistance and weight loss.
• Frontiers and Pharmacology: Presents a systematic review of the efficacy and safety of berberine in various metabolic disorders.
• Journal of Translational Medicine: Contains a meta-analysis on the clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease.
• BMC Endocrine Disorders: Details a study on the effectiveness of berberine in controlling blood sugar levels in people with prediabetes.
• Diabetes Journal: Assesses the quality of clinical trials investigating the effect of berberine on glucose and lipid metabolism in people with prediabetes and diabetes.
• Clinical Nutrition ESPEN: Investigating the effect of dietary supplements with berberine on obesity and metabolic health.
• Metabolism Journal: Reports on a pilot study evaluating the efficacy and safety of berberine in the treatment of type 2 diabetes.
• Alternative Medicine: Highlights the various health benefits of berberine, including its impact on blood sugar and cholesterol.

Disclaimer: The effects of product ingredients are being investigated in scientific studies and further research is ongoing. This product is not intended to diagnose, treat or prevent disease.

Berberine and low carb vs. high carb eating

Diet	How Blood Sugar Breakthrough/ Berberine helps
Low carb	It activates the enzyme AMPK, which promotes fat burning instead of fat storage. It helps the body switch to using fat as fuel, mimicking a state of ketosis or fasting. It increases ATP production and provides more energy, helping to overcome fatigue during the transition to low-carb.
High-carb	It increases insulin sensitivity so the body can use sugars more efficiently instead of storing them in fat. It helps stabilize blood sugar levels after carbohydrate-laden meals such as pizza or Asian cuisine. The product also contains ingredients such as banaba leaf, bitter melon and cinnamon extract, which promote fast carbohydrate processing and reduce sweet cravings.

Read more on this topic

• A BiOptmizers brand like no other - formulations developed by real experts
• Discover low carb or more energy, less sugar
• Introduction to biohacking
• How to improve your workout with the right supplementation

Ingredients

• Biotin - 2 mg (6667% of the daily dose)
  
• Chromium (as chromium picolinate) - 400 µg (1143% of the daily dose)

Proprietary blend:

(638 mg) contains

CyanthOx™ 30 (sea buckthorn fruit extract - 30% proanthocyanidins), African mango, naringin, benfotiamine, R-alpha lipoic acid, banaba leaf extract(20% corosolic acid), Gymnema sylvestre(gurmar) leaf extract and fucoxanthin (10%).

Other ingredients:

• Bitter melon extract (10% charantin) - 200 mg
• GlucoVantage ^® dihydroberberine – 100 mg
• Cinnulin ^PF® Cinnamon Bark Extract (20:1) - 100 mg
• ^InnoSlim® ( blend ginseng a goats) - 75 mg

Other capsule ingredients:

• Hypromellose (vegetable capsule) serves as a capsule shell made from plant materials. It is gelatin-free and therefore suitable for vegetarians and vegans. It is used to safely preserve the contents of the capsules and ensure easy swallowing.
• Rice fiber is commonly used as a filler (improves volume) and stabilizer (maintains consistency) in dietary supplements and foods. It contains insoluble fibre, which may have slightly positive effects on digestion.
• Rice is used as a natural anti-caking agent, which prevents the ingredients from clumping together and keeps the mixture loose. Unlike traditional anti-caking agents such as magnesium stearate, it does not affect nutrient absorption and is gentle on digestion. Thanks to its plant origin, it is suitable for vegetarians, vegans and people with food allergies. Moreover, consumers perceive it as a safe and trustworthy component.

Store in a cool, dry place away from light.

Dosage

• Take 2 capsules approximately 10-15 minutes before each carbohydrate-containing meal.
• If you suffer from any medical condition, consult your physician before taking this dietary supplement.
• Keep out of reach of children.
• If any side effects occur, stop taking the product immediately.

Folders under the microscope

1. ^{GlucoVantage®} Dihydroberberine - 100 mg per dose (2 capsules)

• Why does it make sense?
  This bioactive form of berberine is 5 times more absorbable than regular berberine HCl, meaning that a lower dose has the same effect as 500 mg of regular berberine.
• What does it mean?
  Lower dose = less burden on digestion and lower risk of side effects (such as diarrhoea or upset stomach).

2. Biotin (vitamin B7) - 2 000 mcg per dose

• Why does it make sense?
  Biotin contributes to normal macronutrient metabolism and stabilizes blood sugar levels.
• What does it mean?
  Biotin supports energy metabolism and helps the body process carbohydrates and fats more efficiently, which is important for low-carb eating and weight loss.

3. Chromium (picolinate) - 400 mcg per dose

• Why does it make sense?
  Chromium is an essential mineral that improves insulin sensitivity and helps the body use glucose better.
• What does it mean?
  This dose is higher than the normal recommendation (35 mcg), which is ideal for people who need to stabilize blood sugar or have a problem with insulin resistance. However, the dosage remains within safe limits for long-term use.

4. Plant extracts - synergistic combination (638 mg)

Includes:

• CyanthOx™ 30 - Sea buckthorn(Hippophae rhamnoides) fruit extract, standardized to 30% proanthocyanidins. Proanthocyanidins are polyphenols known for their antioxidant properties that help neutralize free radicals and reduce oxidative stress. In a supplement like BiOptimizers Blood Sugar Breakthrough, these compounds can help support metabolic health and maintain balanced blood sugar levels.
• African mango(Irvingia gabonensis) - A fruit native to West Africa. The seed extract is rich in fiber and has been studied for its possible effects on weight management and blood sugar control. A high soluble fiber content can help improve sugar control by slowing the absorption of carbohydrates. Some studies also suggest that African mango extract may contribute to reducing body fat and improving lipid profile, both key factors for metabolic health.
• Benfotiamine - The fat-soluble form of vitamin B1 (thiamine). Unlike regular thiamine, it has a higher bioavailability, which means it is better absorbed and used by the body. Benfotiamine has been studied for its ability to protect nerves and limit the formation of advanced glycation end products (AGEs). These compounds can contribute to oxidative stress and inflammation if they accumulate in the body. By blocking their formation, benfotiamine can help protect blood vessels, promote nerve health and improve sugar metabolism.
• Banaba leaf (20% corosolic acid) - Leaves of the plant Lagerstroemia speciosa, native to Southeast Asia (Philippines, India). They are traditionally used to support glucose metabolism and maintain healthy blood sugar levels.
• Bitter melon (Momordica charantia) - 10% charantin - 200 mg - Tropical and subtropical plant native to Asia, Africa and the Caribbean. The fruit is traditionally used to promote carbohydrate metabolism and curb sweet cravings.
• Cinnamon Extract (20:1) - 100 mg - Obtained from the bark of the Cinnamomum cassia or Cinnamomum verum tree. It contains the active ingredient polyphenols and coumarins, which are being studied for their effect on glucose metabolism. Research suggests that cinnamon extract may increase insulin sensitivity, thereby helping to regulate blood sugar. According to some studies, it may also slow the breakdown of carbohydrates in the digestive tract, helping to maintain stable glucose levels. Thanks to its antioxidant properties, it protects cells from oxidative stress.
• Gymnema sylvestre (gurmar) - A plant native to India and Africa, known as the "destroyer of sugar". In Ayurvedic medicine, it is traditionally used to reduce sweet cravings and promote glucose metabolism.
• Naringin - A bioflavonoid that occurs naturally in citrus fruits, especially grapefruit. It is known for its antioxidant and anti-inflammatory properties. It is traditionally used to promote fat metabolism and improve nutrient absorption. In the body, it can be metabolized to naringenin, which is being studied for its potential to affect lipid and glucose metabolism.
• R-alpha lipoic acid (R-ALA) - A naturally occurring antioxidant that plays a key role in energy metabolism by helping to convert glucose into energy. Unlike conventional alpha-lipoic acid, it contains only the biologically active form of the R-isomer, which is better absorbed and more effective. It is used to promote insulin sensitivity, regenerate other antioxidants (e.g., vitamin C and E), and protect cells from oxidative stress.
• Fucoxanthin (10%) - A carotenoid derived from marine brown algae such as Wakame (Undaria pinnatifida). This pigment is traditionally used in Asian cuisine and has been studied for its possible effects on fat metabolism. Studies suggest that fucoxanthin may promote fat burning by increasing the activity of so-called. UCP1 protein in adipose tissue, which contributes to thermogenesis (heat production) and energy balance.
• InnoSlim® - 75 mg - A proprietary blend developed by NuLiv Science that combines extracts of ginseng(Panax notoginseng) and valerian(Astragalus membranaceus). Designed to promote glucose absorption into muscles, optimise energy metabolism and improve nutrient absorption.

How can I maintain normal blood sugar levels?

Maintaining stable blood sugar levels is crucial not only for diabetes prevention, but also for overall health, energy and vitality. Modern approaches combine traditional recommendations with alternative strategies and technologies to help keep glucose under control.

A balanced diet as a foundation

Eat a low-glycaemic diet rich in protein, healthy fats and fibre to help slow the absorption of sugar.

Avoid foods high in refined sugars and simple carbohydrates, which can cause sharp fluctuations in glucose levels. Research recommends including, for example, whole grains, legumes, nuts, seeds, vegetables and fruits with a low glycemic index.

Regular exercise and physical activity

Regular exercise helps increase insulin sensitivity and promotes efficient glucose utilization in the muscles. It is recommended that you do some sport at least 5 days a week, for example brisk walking, running, cycling or swimming for 30 minutes a day.

In addition, weight training 2-3 times a week improves sugar metabolism and promotes fat burning.

Optimising sleep and stress management

Quality sleep is essential for hormonal balance and insulin sensitivity. Lack of sleep increases the production of stress hormones such as cortisol, which can stimulate the production of glucose in the liver.

Try to sleep at least 7-8 hours a day and establish a regular sleep schedule. Managing stress through yoga, meditation or breathing exercises can further help stabilise your sugar levels.

Technology for controlling sugar levels

Modern continuous glucose monitoring (CGM) devices allow real-time monitoring of blood sugar levels.

This provides immediate feedback on how food, exercise or stress is affecting glucose levels, helping to tailor your daily routine and diet to your current needs.

Natural blood sugar support with herbs, spices and mushrooms

A number of natural ingredients are traditionally used to support blood sugar balance and metabolism. Gymnema sylvestre (gurmar) a cinnamon are known for their ability to help maintain insulin sensitivity and curb sweet cravings.

Ginger a turmeric are valued not only for their antioxidant properties, but also for supporting proper metabolic function.

Fenugreek Greek hay is traditionally used in Ayurveda to aid digestion and nutrient absorption, while aloe vera a basil are associated with promoting blood sugar balance.

Rosemary a garlic are rich in bioactive substances that are considered beneficial in natural medicine for overall metabolic balance.

Of the mushrooms stand out maitakewhich contain natural ingredients that slow down the digestion of carbohydrates and thus help maintain more stable sugar levels.

It is ideal to consume all these supplements at least 10 - 15 minutes before meals.

These ingredients can be useful as part of a balanced diet and healthy lifestyle, and it is advisable to consult a nutritionist or doctor about their use.

How to combine BiOptimizers supplements for keto, paleo and low-carb diets?

Basic principles by type of food

On these diets, there is protein + fat in almost every meal, so we'll be taking Kapex and MassZymes as base supplements for almost all meals. HCL Breakthrough is only used in specific cases.

1. Types of dishes and how to deal with them correctly

A) Low-fat, high-protein food

Example of meals:

• Steamed skinless chicken breast + vegetables.
• White fish (cod, tilapia) on water + rice.
• Egg whites or low-fat cottage cheese.

Main problem:

• Low fat → lack of bile for digestion.
• Protein needs more acid and enzymes to break it down.

Accessories:

• HCL Breakthrough (1-2 capsules at the end of a meal): Supports stomach acid needed for protein digestion.
• MassZymes (1-2 capsules 10-15 minutes before meals): supports the enzymatic breakdown of proteins into amino acids.
• P3-OM (1 capsule in the morning or at bedtime): Strengthens the microbiome and supports gut regeneration.

B) High-fat, high-protein food (keto/paleo)

Example of meals:

• Steak in butter + avocado.
• Fried eggs with bacon.
• Salmon on ghee + steamed broccoli.

Main problem:

• The high fat content requires bile and enzymes.
• Proteins need strong enzymatic support.

Accessories:

• Kapex (2-4 capsules 10-15 minutes before meals): optimizes fat and protein digestion.
• MassZymes (1 capsule optionally 10-15 minutes before a meal): if there is a lot of protein in the meal, it will add an extra boost.
• P3-OM (1 capsule in the evening before bed): support of the intestines and immunity.

C) Higher carbs - Low-carb with some carbs

Example of meals:

• Duck with red cabbage + rye bread.
• Chicken + roasted vegetables + potatoes.
• Sushi or light pasta with vegetables.

Main problem:

• Blood sugar fluctuations - risk of fat storage.
• The need to keep insulin under control.

Accessories:

• Berberine Breakthrough (2 capsules 10-15 minutes before meals): Stabilizes sugar and improves insulin sensitivity.
• Kapex (2 capsules 10-15 minutes before meals): Supports the digestion of fats and proteins.
• Gluten Guardian (2 capsules before meals 10-15 minutes before meals): if gluten or lactose is suspected.

D) Cheat meals - Pizza, pasta, sushi

Example of meals:

• Pizza with cheese and sausage.
• Pasta with cream sauce.
• Sushi with rice and soy sauce.

Main problem:

• Sugars, gluten, dairy products.
• Risk of bloating, sugar spikes or intolerances.

Accessories:

• Berberine Breakthrough (2 capsules before meals 10-15 minutes before meals): stabilizes blood sugar.
• Kapex (2 capsules 10-15 minutes before meals): fat and protein support.
• Gluten Guardian (2 capsules before meals 10-15 minutes before meals): for gluten and lactose - hidden in sauces or dough.
• P3-OM (1 capsule in the evening before bedtime): for bowel regeneration.

E) Fibre or vegetarian food

Example of meals:

• Salad with mozzarella, olive oil.
• Steamed vegetables or legumes.

Main problem:

• Bloating and slow fiber digestion.

Accessories:

• VegZymes (1 capsule before meals 10-15 minutes before meals): Digests fiber and carbohydrates, prevents flatulence.
• P3-OM (1 capsule in the morning on an empty stomach or in the evening before bed): bowel support and prevention of bloating.

2. What to do when you eat in a restaurant?

Hidden gluten and lactose:

• Many sauces, soups or marinades contain gluten, lactose or thickeners.
• Solution: Always take Gluten Guardian (2 capsules 10-15 minutes before eating) so you don't get surprised.

Unknown fats and ingredients:

• Kapex (2 capsules 10-15 minutes before meals): if the food is likely to be fatty (fried, sauces).
• HCL Breakthrough (1 capsule at the end of the meal): if the meal is rather low-fat but has a lot of protein.

Attention

• Kapex and HCL Breakthrough are not combined at one meal - choose according to the type of meal.
• Use strategically:
  • Kapex = Fats and proteins.
  • HCL Breakthrough = Low Fat Proteins.
• P3-OM = Microbiome and immunity - in the morning on an empty stomach or in the evening before going to bed